Publications
LAB PUBLICATIONS
2022
Oliveira MM, Bonturi CR, Salu BR, Oliva MLV, Mortara RA & Orikaza CM. 2022. Modulation of STAT-1, STAT-3, and STAT-6 activities in THP-1 derived macrophages infected with two Trypanosoma cruzi strains. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.1038332
Castro Neto AL, Silveira JF & Mortara RA. 2022. Role of virulence factors of trypanosomatids in the insect vector and putative genetic events involved in surface protein diversity. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2022.807172
Bonifácio BS, Bonfim-Melo A, Mortara RA & Ferreira ER. 2022. Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeleton. Journal of Eukaryotic Microbiology. https://doi.org/10.1111/jeu.12903
Teixeira TL, Chiurillo MA, Lander N, Rodrigues CC, Onofre TS, Ferreira ER, Yonamine CM, Santos JG, Mortara RA, Silva CF & Silveira JF. 2022. Ablation of the P21 gene of Trypanosoma cruzi provides evidence of P21 as a mediator in the control of epimastigote and intracellular amastigote replication. Frontiers in Cellular and Infection Microbiology https://doi.org/10.3389/fcimb.2022.799668
2021
Silva NSL, Orikaza CM, Santana FR, Santos LA, Salu BR, Oliva MLV, Sinigaglia RC, Mortara RA. 2021. Interleukin-9 in immunopathology of Trypanosoma cruzi experimental infection. Frontiers in Cellular and Infection Microbiology, 7567521. https://doi.org/10.3389/fcimb.2021.756521
Ferreira EA, Bonfim-Melo A, Burleigh BA, Costales JA, Tyler JM & Mortara RA. Parasite-mediated remodeling of the host microfilament cytoskeleton enables rapid egress of Trypanosoma cruzi following membrane rupture. mBio, https://journals.asm.org/doi/10.1128/mBio.00988-21
Castro Neto AL, da Silveira JF, Mortara RA. Comparative analysis of virulence mechanisms of Trypanosomatids pathogenic to humans. Frontiers in Cellular and Infection Microbiology 11:669079. doi: 10.3389/fcimb.2021.669079.
Medina CM, Ferreira ÉR, Bonifácio BS, Mortara RA, Bonfim-Melo A.Trypanosoma cruzi extracellular amastigotes engage Rac1 and Cdc42 to invade RAW macrophagesMicrobes and Infection 3:104837. doi: 10.1016/j.micinf.2021.104837.
Florentino PTV, Mendes D, Vitorino FNL, Martins DJ, Cunha JPC, Mortara RA, Menck CFM. DNA damage and oxidative stress in human cells infected by Trypanosoma cruzi. PLoS Pathogens 17(4):e1009502. doi: 10.1371/journal.ppat.1009502.
2020
Bernardo WP, Souza RT, Costa-Martins AG, Ferreira ER, Mortara RA, Teixeira MMG, Ramirez JL, Da Silveira JF Genomic Organization and Generation of Genetic Variability in the RHS (Retrotransposon Hot Spot) Protein Multigene Family in Trypanosoma cruzi. Genes (Basel). 2020. 11(9):E1085. doi: 10.3390/genes11091085.
Orikaza CM, Pessoa CC, Paladino FV, Florentino PTV, Barbiéri CL, Goto H, Ramos-Sanchez EM, da Silveira JF, Rabinovitch M, Mortara RA, Real F. Dual host-intracellular parasite transcriptome of enucleated cells hosting Leishmania amazonensis: control of half-life of host cell transcripts by the parasite. Infect Immun. 2020 doi: 10.1128/IAI.00261-20.
Targeting intracellular Leishmania (L.) infantum with nitazoxanide entrapped into phosphatidylserine-nanoliposomes: An experimental study. Pinto EG, Barbosa LRS, Mortara RA, Tempone AG. Chem Biol Interact. 2020. doi: 10.1016/j.cbi.2020.109296.
2019
Moretti, N.S., Mortara, R.A. & Schenkman, S. Trypanosoma cruzi. Parsite of the month. Trends in Parasitology, in press. DOI: https://doi.org/10.1016/j.pt.2019.10.002 Paper
Ferreira, B.L, Bonfim-Melo, A., Ferreira, E.R., Mortara, R.A. & Bahia, D. 2019. Trypanosoma cruzi extracellular amastigotes selectively trigger PI3K-Akt and Erk pathways during host-cell invasion. Microbes and Infection, 21: 485-489. DOI:10.1016/j.micinf.2019.06.003 Paper
Cunha, F.F.M., Mugnol, K.C.U., Melo, F.M., Silva Queiroz Nascimento, M.V., Azevedo, R.A., Santos, R.T.S., Magalhães, J.A,, Miguel, D.C., Tada, D.B., Mortara, R.A., Travassos, L.R. & Arruda, D.C. 2019. Peptide R18H from Brn-2 transcription factor POU domain displays antitumor activity in vitro and in vivo and induces apoptosis in B16F10-Nex2 cells.Anticancer Agents in Medicinal Chemistry, doi: 10.2174/1871520618666181109164246
Gonzatti, M.B., Sousa, M.E.P., Tunissi, A.S., Mortara, R.A., de Oliveira, A.M., Pereira Cerize, N.N. & Keller, A.C. 2019. Nano spray dryer for vectorizing α-galactosylceramide in polymeric nanoparticles: A single step process to enhance invariant Natural Killer T lymphocyte responses. International Journal of Pharmacology, 565:123-132. doi: 10.1016/j.ijpharm.2019.05.013.
Pessoa, C.C., Reis, L.C., Ramos-Sanchez, E.M., Orikaza, C.M., Cortez, C., Levatti, E.V.C., Badaró, A.C.B., Yamamoto, J.U.S., D’Almeida, V., Goto, H., Mortara, R.A.& Real, F. 2019; ATP6V0d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis. Plos Pathogens, 15 (6): e1007834. DOI: 10.1371/journal.ppat.1007834 Paper
2018
Bonfim-Melo, A., Ferreira, E.R., Florentino, P.V. & Mortara, R.A. 2018. Amastigote synapse: the tricks of Trypanosoma cruzi extracellular amastigotes. Frontiers in Microbiology. Microbial Immunity, doi: 10.3389/fmicb.2018.01341. Paper
Bonfim-Melo, A., Ferreira, E.R. & Mortara, R.A. 2018. Rac1/WAVE2 and Cdc42/N-WASP participation in actin-dependent host cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 9: 360. doi:10.3389/fmicb.2018.00360. Paper
Ferreira, B.L., Ferreira, E.R., Brito, M.V., Salu, B.R., Oliva, M.L.V., Mortara, R.A. & Orikaza, C.M. 2018. BALB/c and C57BL/6 mice cytokine responses to Trypanosoma cruzi infection are independent of parasite strain infectivity. Frontiers in Microbiology, 9:553.doi: 10.3389/fmicb.2018.00553. Paper
Florentino, P.T.V., Real, F., Orikaza, C.M., Cunha, J.P.C., Vitorino, F.N.L., Cordero, E.M., Sobreira, T.J.P. & Mortara, R.A. 2018. A carbohydrate moiety of secreted Stage-specific glycoprotein 4 participates in host cell invasion by Trypanosoma cruzi extracellular amastigotes. Frontiers in Microbiology, 9: 693. doi 10.3389/fmicb.2018.00693 Paper
Reis, R.I., Nogueira, M.D., Campanha-Rodrigues, A.L., Pereira, L.M., Andrade, M.C.C., Parreiras-e-Silva, L.T., Costa Neto, C.M., Mortara, R.A. & Casarini, D.E. 2018. The binding of Captopril to Angiotensin-I Converting Enzyme triggers signaling pathways activation. American Journal of Physiology. Cell Physiology, 315: C367-C369 doi: 10.1152/ajpcell.00012.2016.
2017
Ferreira, E.R., Bonfim-Melo, A., Cordero, E.M. & Mortara, R.A. ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 8: 2230. doi: 10.3389/fmicb.2017.02230. Paper
Gutierre, R.C., Vanucci Campos, D., Mortara, R.A., Coppi, A.A. & Arida, R.M. 2017. Reflection imaging of china ink-perfused brain vasculature using confocal laser scanning microscopy after clarification of brain tissue by the Spalteholz method. Journal of Anatomy, 230: 601-606. doi: 10.1111/joa.12578. Trabalho destacado pela Unifesp (link), Neurosciencenews.com (link), University of Surrey link e Revista Pesquisa FAPESP (link).
Di Genova, B.M., Silva, R.C., Gargantini, P.R., Mortara, R.A. & Tonelli, R.R. 2017. Protein SUMOylation is involved in cell-cycle progression and cell morphology in Giardia lamblia. Journal of Eukaryotic Microbiology 64: 491-503. doi: 10.1111/jeu.12386
Santos, J.C., Heinhuis, B., Gomes, R.S., Damen, M.S.M.A., Real, F., Mortara, R.A., Keating, S.T., Dinarello, C.A., Joosten, L.A.B. & Ribeiro-Dias, F... 2017. Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species. PloS Neglected Tropical Diseases, 11(2): e0005413. doi: 10.1371/journal.pntd.0005413 Paper
Teixeira,S.C., Lopes, D.S., Gimenes, S., Teixeira, T.L., Silva, M., Silva, R., Luz,F., Silva, A.A., Silva, S., Florentino, P., Brigido, P., Santos, M.A., Ávila, V., Silva, M.J.B., Elias, M.C., Mortara, R.A. & Silva, C.V. 2017. Mechanistic insights into the anti-angiogenic activity of Trypanosoma cruzi protein 21 and its potential impact on the onset of chagasic cardiomyopathy. Scientific Reports, 7: 44978. doi:10.1038/srep44978 Paper
Maza, P.K., Bonfim-Melo, A., Padovan, A.C., Mortara, R.A., Orikaza, C.M., Ramos, L., Moura, T., Soriani, F.M., Almeida, R., Suzuki, E., & Bahia, D. 2017. Candida albicans: the ability to invade epithelial cels and survive under oxidative stress is unlinked to hyphal length. Frontiers in Microbiology, 8: 1235 doi: 10.3389/fmicb.2017.01235 Paper
Levatti, E.V.C., Toledo, M.S., Costa, R.W., Bahia, D., Mortara, R.A., Takahashi, H.K, & Straus, A.H. 2017. Leishmania (Viannia) braziliensis inositol phosphorylceramide: Distinctive sphingoid base composition. Frontiers in Microbiology, 8: 1453 doi: 10.3389/fmicb.2017.01453 Paper
Ribeiro, G.M., Matsumoto, C.K., Real, F., Teixeira, D., Duarte, R.S., Mortara, R.A., Leão, S.C. & Wodarz, C.C.S. 2017. Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. BMC Microbiology, 17: 195 doi: 10.1186/s12866-017-1102-7 Paper
Silva, A.A., Teixeira, T.L., Teixeira, S.C., Machado, F.C., Santos, M.A., Tomiosso, T.C., Tavares, P.C., Brigido, R.T., Martins, F.A., Silva, N.S., Rodrigues, C.C., Roque-Barreira, M.C., Mortara, R.A., Lopes, D.S., Ávila, V., Silva, C.V. Galectin-3: a friend but not a foe during Trypanosoma cruzi experimental infection. Frontiers in Cellular and Infection Microbiology, 7: 463 doi:10.3389/fcimb.2017.00463. Paper
Pérez, EC.,, Xander, P., Laurindo, M.F., Brito, R.R.N., Vivanco, B.C., Mortara, R.A., Mariano, M., Lopes, J.D. Keller, A.C. 2017. The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes. PlosOne, 12 (11): e0187333. doi: 10.1371/journal.pone.0187333. Paper
Sharma, N.K., Tashima, A.K., Brunialti, M.K.C., Ferreira, E.R., Torquato, R.J.S., Mortara, R.A., Machado, F.R., Assunção, M., Rigato, O. & Salomão, R. 2017. Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia. Scientific Reports, 7: 15606. Paper
2016
Ferreira, B.L., Orikaza, C.M., Cordero, E.M. & Mortara, R.A. Trypanosoma cruzi: single cell live imaging inside infected tissues. Cellular Microbiology, 18: 779-783. doi: 10.1111/cmi.12553. Paper
Pessoa, C.C., Ferreira, E.R., Bayer-Santos, E., Rabinovitch, M., Mortara, R.A. & Real, F. Trypanosoma cruzi differentiates and multiplies within chimeric parasitophorous vacuoles in macrophages coinfected with Leishmania amazonensis. Infection and Immunity, 84:1603-1614. doi: 10.1128/IAI.01470-15 Paper
Destaque dos trabalhos de capa na Agência FAPESP de 20 de maio de 2016: Link
Okada, S.S., Oliveira, E.M., Araújo, T.H., Rodrigues, M.R., Albuquerque, M.C., Mortara, R.A., Taniwaki, N.N., Nakaya, H.I. & Campa, A. 2015. Myeloperoxidase in human peripheral blood lymphocytes: production and subcellular localization. Cellular Immunology, 300: 18-25.doi: 10.1016/j.cellimm.2015.11.003 Paper
Ferreira, E.R., Horjales, E., Cortez, C., Silva, C.V., De Groote, M., Sobreira, T.J.P., Cruz, M.C., Lima, F.M., Bonfim-Melo, A., Cordero, E.M., Yoshida, N., Silveira, J.F., Mortara, R.A. & Bahia, D. Unique behavior of Trypanosoma cruzi mevalonate kinase: a conserved glycosomal enzyme involved in host cell invasion and signaling. Scientific Reports, doi: 10.1038/srep24610 Paper
Destaque do trabalho na Revista Pesquisa FAPESP online em 12 de outubro de 2016: Link
Rabaça, A.N., Arruda, D.C., Figueiredo, C.R., Massaoka, M.H., Maia, V., Farias, C.F., Tada, D.B., Silva Junior, P.I., Real, F., Mortara, R.A., Polonelli, L., Travassos, L.R.2016. AC-1001 H3 CDR peptide induces apoptosis and autophagy signs in vitro and exhibits antimetastatic activity in a syngeneic melanoma model. FEBS Open Bio, 6: 885-901. doi: 10.1002/2211-5463.12080 Paper
Polonelli, L., Ciociola, T., Elviri, L., Zanello, P.P., Giovati, L., Arruda, D.C., Muñoz, J.E., Mortara, R.A., Morace, G., Borghi, E., Galati, S., Marin, O., Casoli, C., Pilotti, E., Ronzi, P., Travassos, L.R., Magliani, W. & Conti, S. A Naturally occurring antibody fragment neutralizes infectivity of diverse infectious agents. Scientific Reports: 35018. doi: 10.1038/srep35018 Paper
2015
Wang, P.H.M., Andrade, M.C.C, Di Marco, G.S., Mortara, R.A., Vio, C.P., & Casarini, D.E. 2015. N-domain of angiotensin I - converting enzyme N-is expressed in immortatalized mesangial, proximal tubule and collecting duct cells. International Journal of Biological Macromolecules, 72: 380-390. doi:10.1016/j.ijbiomac.2014.07.043 Paper
Bonfim-Melo, A., Zanetti, B.F., Ferreira, E.R., Vandoninck, S., Han, S.W., Van Lint, J., Mortara, R.A. & Bahia, D. 2015. Trypanosoma cruziextracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasion. Cellular Microbiology, 17: 1797-1810. doi: 10.1111/cmi.12472 Paper
Destaque do trabalho na Revista Pesquisa FAPESP online em 12 de outubro de 2016: Link
Teixeira, T.L., Cruz, L., Mortara, R.A. & Silva, C.V. 2015. Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction. Parasites and Vectors, 8: 493. Paper
2014
Florentino, P.T.V., Real, F., Bonfim-Melo, A., Orikaza, C.M., Ferreira E.R., Pessoa, C.C., Lima, B.R., Sasso, G. & Mortara R.A. 2014. An historical perspective on how advances in microscopic imaging contributed to understanding the Leishmania spp. and Trypanosoma cruzi host-parasite relationship. BioMed Research International, 2014: 565291. doi:10.1155/2014/565291. Paper & Supplementary Material
Machado, F.C., Cruz, L., Silva, A.A., Cruz, M.C., Mortara, R.A., Roque-Barreira, M.C. & Silva, C.V. 2014. Galectin-3 recruitment during Trypanosoma cruzi extracellular amastigotes cell invasion and intracellular traffic. Glycobiology, 24: 179–184. Paper
Santos, M.A., Teixeira, F.B, Moreira, H.H.T., Rodrigues, A.A., Machado, F.C., Clemente, T.M., Brigido, P.C., Tavares e Silva, R., Purcino, C., Gomes, R.G.B, Bahia, D., Mortara, R.A., Munte, C.E., Horjales, E. & Vieira da Silva, C. 2014. A successful strategy for the recovery of active P21, an insoluble recombinant protein of Trypanosoma cruzi. Scientific Reports, 4: 4259. Paper
Dourado, I.B.Z., Batista, W.L., Longo, L.V.G., Mortara, R. A., Puccia, R. 2014. Dual localization of Mdj1 in pathogenic fungi varies with growth temperature. Medical Mycology, 52: 187-195. Paper
Gonçalves, V.M., D’Almeida, V., Müller, K.B., Real, F. & Mortara, R.A. 2014. Lysosomal integral membrane protein 2 (LIMP-2) restricts the invasion of Trypanosoma cruzi extracellular amastigotes through the activity of the lysosomal enzyme β-glucocerebrosidase. Microbes and Infection, 16: 253-260. Paper
Oliveira, P., Lima, F.M., Cruz, M.C., Ferreira, R.C., Flores, A.S., Cortez, D.R., Ferreira, E.R., Real, F., Briones, M.R.S., Mortara, R.A., Silveira, J.F. & Bahia, D. 2014. Trypanosoma cruzi: Genome characterization of phosphatidylinositol kinase gene family (PIK and PIK-related) and identification of a novel PIK gene. Infection, Genetics and Evolution, 25: 157-165. Paper
Claro, S., Oshiro, M.E.M., Mortara, R.A. & Ferreira, A.T., 2014. g-Rays-generated ROS induce apoptosis via mitochondrial and cell cycle alteration in smooth muscle cells. International Journal of Radiation Biology, doi:10.3109/09553002.2014.911988. Paper
Cruz-Leal, Y., Machado, Y., López-Requena, A., Canet, L., Laborde, R., Alvares, A.M., Laurindo, M.F.L., Tomas, J.F.S., Alonso, M.E., Álvarez, C., Mortara, R.A., Popi, A.F., Mariano, M., Pérez, R., & Lanio, M.E. Role of B-1 cells in the immune response against an antigen encapsulated into phosphatidylcholine-containing liposomes. International Immunology, doi:10.1093/intimm/dxu042. Paper
2013
Lima, F.M., Souza, R.T., Santori, F.R., Santos, M.F., Cortez, D.R., Barros, R.M., Cano, M.I., Valadares, H.M., Macedo, A.M., Mortara, R.A., & Silveira, J.F. 2013. Interclonal variations in the molecular karyotype of Trypanosoma cruzi: chromosome rearrangements in a single cell-derived clone of the G strain. PLoS One, 8(5): e63738 Paper
Gomes da Silva, S., Rodrigues-Simões, P.S. Mortara, R.A., Scorza, F.A., Naffat-Mazzacoratti, M.G. & Arida, R.M. 2013. Exercise-induced hippocampal anti-inflammatory response in aged rats. Journal of Neuroinflammation, 10: 61 Paper
Kangussu-Marcolino, M.M., Cardoso de Paiva, R.M., Araujo, P.R., Mendonça-Neto, R.P., Lemos, L., Bartholomeu, D.C., Mortara, R.A., DaRocha, W.D. & 2013. Distinct genomic organization, mRNA expression and cellular localization of members of two amastin sub-families present in Trypanosoma cruzi. BMC Microbiology, 13(1) 10. Paper Supplemental Material
Gonçalves, L.C.P., Tonelli, R.R., Bagnaresi, P., Mortara, R.A., Ferreira, A.G., & Bastos, E.L. 2013. A nature-inspired betalainic probe for live-cell imaging of Plasmodium-infected erythrocytes. PLoS One 8(1): e53874 Paper
Fernandes, M.C., Flannery, A., Andrews, N.W & Mortara, R.A. 2013. Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells. Cellular Microbiology, 15: 977–991. Paper
Araújo, T.H, Okada, S.S., Ghosn, E.S., Taniwaki, N.N., Rodrigues, M.R., Almeida, S.R., Mortara, R.A., Russo, M. & Campa, A. 2013. Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages. Cellular Immunology, 281: 27-30. Paper
Lima, F.F.B., Sita, L.V., Oliveira, A.R., Costa, H.C., Silva, J.M., Mortara, R.A., Haemmerle, C.A.S., Xavier, G.F., Canteras, N.F., & Bittencourt, J.C. 2013. Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat. Journal of Chemical Neuroanatomy, 47: 1-14. Paper
Real, F., Vidal, R.O., Carazzolle, M.F., Mondego, J.M.C., Costa, G.G.L., Herai, R.H., Würtele, M., Carvalho, L.M., Ferreira, R.C., Mortara, R.A., Barbiéri, C.L., Mieczowski, P., Silveira, J.F., Briones, M.R.S., Pereira, G.A.G. & Bahia, D. 2013. The genome sequence of Leishmania (Leishmania) amazonensis: 1 functional annotation and extended analysis of gene models. DNA Research, 20: 567-581. Paper. Highlighted in revista Pesquisa FAPESP here.
2012
Real, F. & Mortara, R.A. 2012. The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. PLoS Neglected Tropical Diseases, 6: e1518. Paper
Silva, S.G., Unsain, N., Mascó, D.H., Michelle Toscano-Silva, M., Amorim, H.A., Araújo, B.H.S., Rodrigues-Simões, P.S., Naffah-Mazzacoratti, M.G., Mortara, R.A., Scorza, F.A., Cavalheiro, E.A. & Arida, R.M. 2012. Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats. Hippocampus, 22: 347-358. Paper
Arruda, D.C., Santos, L.C.P., Melo, F.M., Pereira, F,V, Figueiredo, C.R., Matsuo, A.L, Mortara, R.A., Juliano, M.A, Rodrigues, E.G., Dobroff, A.S., Polonelli, L. & Travassos, L.R. 2012. The b-actin-binding complementarity-determining region 2 (CDR-2) synthetic peptide from mAb C7-heavy chain induces apoptosis in several human tumor cells and is protective against metastatic melanoma. The Journal of Biological Chemistry, 287: 14912 - 14922. Paper
Rodrigues, A.A, Clemente, T.M., Santos, M.A., Machado, F.C., Gomes, R.G.B., Moreira, H.H.T., Cruz, M.C., Brígido, P.C., Santos, P.C.F., Martins, F.A., Bahia, D., Maricato, J.T., Janini, L.M.R., Reboredo, E.H., Mortara, R.A. & Silva, C.V. A recombinant protein based on Trypanosoma cruzi P21 enhances phagocytosis. PLoS One, 7(12): e51384. Paper
Cruz, M.C., Souza-Melo, N. da Silva, C.V., DaRocha, W.D. Bahia, D., Araújo, P.R., Teixeira, S.R. & Mortara, R.A. 2012. Trypanosoma cruzi: role of d-amastin on extracellular amastigote cell invasion and differentiation. PLoS One, 7(12): e51804 Paper Correction
Ferreira, E.R., Bonfim-Melo, A., Mortara, R.A. & Bahia, D. 2012. Trypanosoma cruzi extracellular amastigotes and host cell signaling: more pieces to the puzzle. Frontiers in Immunology, 3: 363. Paper Commentary on Global Medical Discovery
Lozano, E., Barrera, P., Salinas, R., Vega, I., Nieto, M., Tonn, C., Kemmerling, U., Mortara, R.A., & Sosa, M.A. 2012. Sesquiterpene lactones and the diterpene 5-epi-icetexone affect the intracellular and extracellular stages of Trypanosoma cruzi. Parasitology International, 61: 628-633. Paper
2011
Fernandes, M.C., Cortez, M., Flannery, A.R., Tam, C., Mortara, R.A. & Andrews, N.W. 2011. Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. The Journal of Experimental Medicine, 208: 909-921. Paper . This paper was highlighted in Cell and Nature Reviews in Microbiology.
Simões, P.S.R., Perosa, S.R., Arganãraz, G.A., Yacubian, E.M., Carrete Jr., H., Centeno, R.S., Varella, P.P.V. , Santiago, J.F.C., Canzian, M., Silva Jr., J.A., Mortara, R.A., Amado, D., , Cavalheiro, E.A. & Mazzacoratti, M.G.N. 2011. Kallikrein 1 is overexpressed by astrocytes in the hippocampus of patients with refractory temporal lobe epilepsy, associated with hippocampal sclerosis. Neurochemistry International, 58: 477-482. Paper
Taniwaki, N.N., Gonçalves, V.M., Romero, J.K., Silva, C.V., Silva, S. & Mortara, R.A. 2011. Trypanosoma cruzi strains in the Calomys callosus: parasitemia and reaction of intracellular forms with stage-specific antibodies in the acute and chronic phase of infection and after immunosuppression. Parasitology Research, 109: 431-440. Paper
Kioshima, E.S., Aliperti, F., Maricato, J.T., Mortara, R.A., Bagagli, E., Mariano, M. & Lopes, J.D. 2010. A synthetic peptide discriminates and kills only virulent Paracoccidiodes brasiliensis yeasts. Microbes and Infection, 13: 251-260. Paper
Calderano, S.G., Godoy, P.D.M., Motta, M.C.M., Mortara, R.A., Schenkman, S. & Elias, M.C. 2011. Trypanosoma cruzi DNA replication includes the sequential recruitment of pre-replication and replication machineries close to nuclear periphery. Nucelus, 2: 135-146. Paper
Ramos, C.S., Yokoyama-Yasunaka, J.K.U., Guerra-Giraldez, M.C., Price, H.P., Mortara, R.A., Smith, D.F. & Uliana, S.R.B. 2011. Leishmania amazonensis META2 confers protection against heat shock and oxidative stress. Experimental Parasitology, 127: 228-237. Paper
Calabrese, K.S., Silva, L.S., Carvalho, L.O.P., Hardoim, D.J., Silva-Almeida, M., Mortara, R.A. & Souza, C.S.F. 2011. Infection of retinal epithelial cells with L. amazonensis impactsin extracellular matrix proteins. Parasitology Research, 109: 727-736. Paper
Aragão, D.S., Cunha, T.S., Arita, D.Y., Andrade, M.C.C., Fernandes, A.B., Watanabe, I.K.M., Mortara, R.A. & Casarini, D.E., 2011. Purification and characterization of angiotensin converting enzyme 2 (ACE2) from murine model of mesangial cell in culture. International Journal of Biological Macromolecules, 49: 79-84. Paper
Flannery, A., Huynh, C., Mittra, B., Mortara, R.A. & Andrews, N.W. 2011. The LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms. The Journal of Biological Chemistry, 286: 23266-23279. Paper
Galetovic´, A. C., Souza, R.T., Santos, M.R.M., Cordero, E., Santana, J., Ruiz, J.C., Lima, F. M., Marini, M., Mortara, R.A. & Silveira, J.F. 2011. The repetitive cytoskeletal protein H49 of Trypanosoma cruzi is a calpain-like protein located at the flagellum attachment zone. PLoS One, 11 (6): e27634. Paper & Supplement
Fernandes, M.C., Andrade, L.R., Andrews, N.W. & Mortara, R.A. 2011. Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion. Memórias do Instituto Oswaldo Cruz, (Rio de Janeiro), 106: 1014-1016. Paper
2000 - 2010
Silva, A.G.S., Graves, H.A., Guffei, A., Ricca, T.I., Mortara, R.A., Jasiulionis, M.G. & Mai, S. 2010. Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma. Neoplasia, 12: 11-19. Paper
Lima, F.M., Oliveira, P., Mortara, R.A., Silveira F, J. & Bahia, D. The challenge of Chagas' disease: has the human pathogen, Trypanosoma cruzi, learned how to modulate signalling events to subvert host cells? New Biotechnology, 27: 837-843. Paper
Dobroff, A.S., Rodrigues, E.G., Juliano MA, Friaça, D.M., Nakayasu, E.S., Almeida, I.C., Mortara, R.A., Jacysyn, J.F., Amarante-Mendes, G.P., Magliani, W., Conti, S., Polonelli, L., & Travassos, L.R. Differential antitumor effects of IgG and IgM monoclonal antibodies and their synthetic complementary determining regions directed to new targets of B16F10-Nex 2 melanoma cells. Translational Oncology, 3: 204-217. Paper
Tempone, A.G., Mortara, R.A., Andrade Jr., H.F., & Reimão, J.Q. 2010. Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis. International Journal of Antimicrobial Agents, 36: 159-163. Paper
Lione, V.O.F., Santos, M.H.B., Carvalho, T.M.U., Hirata Jr, R., Mattos-Guaraldi, A.L., Mortara, R.A., & Nagao, P.E. 2010. Fever temperature enhances mechanisms of survival of Streptococcus agalactiae within human endothelial cells. International Journal of Molecular Medicine, 26: 511-516. Paper
Martin, R.P., Rodrigues, E.S., Corrrea, S.A.A., Oliveira, S.M., Mortara, R.A., Oliveira, L., Nakaie, C.R. & Shimuta, S.I. 2010. Role of the second SS bridge (Cys18-Cys274) in stabilizing the inactive AT1 receptor. Biological Chemistry, 391: 1189-1195. Paper
Real, F., Mortara, R.A. & Rabinovitch, M. 2010. Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. PLoS Neglected Tropical Diseases, 4(12): e905 Paper S1, S2, S3
Silva, C.V., Silva, E.A., Cruz, M.C., Chavrier, P. & Mortara, R.A. 2009. ARF-6, PI3-kinase and host cell actin cytoskeleton in Toxoplasma gondii cell invasion. Biochemical and Biophysical Research Communications, 378: 656-661. Paper
Alves, M.J.M. & Mortara, R.A. 2009. A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells? Memórias do Instituto Oswaldo Cruz, 104 (Suppl. I): 76-88. Paper
Silva, C.V., Kawashita, S.Y., Probst, C.M., Dallagiovanna, B., Cruz, M.C., Silva, E.A., Souto-Padrón, T.C., Krieger, M.A., Goldenberg, S., Briones, M.R.S., Andrews, N.W. & Mortara, R.A. 2009. Characterization of a 21 kDa protein from Trypanosoma cruzi associated with mammalian cell invasion. Microbes and Infection, 11: 563-570. Paper & Supplement
Oliveira, M.P.C., Javier, M.C., Maeda, F.Y., Fernandes, M.C., Haapalainen, E.F, Yoshida, N. & Mortara, R.A. 2009. Unique behavior of Trypanosoma dionisii interacting with mammalian cells: invasion, intracellular growth, and nuclear localization. Acta Tropica, 110: 65-74. Paper & Supplement
Popi, A.F., Zamboni, D.S., Mortara, R.A. & Mariano, M. 2009. Microbicidal property of B1 cell derived mononuclear phagocyte. Immunobiology, 214: 664-673. Paper
Kawashita, S.Y., Silva, C.V., Mortara, R.A., Burleigh, B.A. & Briones, M.R.S. 2009. Homology, paralogy and function of DGF-1, a highly dispersed Trypanosoma cruzi specific gene family and its implications for information entropy of its encoded proteins. Molecular and Biochemical Parasitology, 165: 19-31. Paper & Supplement
Bahia, D., Oliveira, L.M., Mortara, R.A. & Ruiz, J.C. 2009. Phosphatidylinositol - and related- kinases: A genome-wide survey of classes and subtypes in the Schistosoma mansonigenome for designing subtype-specific inhibitors. Biochemical and Biophysical Research Communications, 380: 525-530. Paper
Popi, A.F., Motta, F.L.T., Mortara, R.A., Schenkman, S. Lopes, J.D. & Mariano, M. 2009. Coordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocyte in vitro. Immunology, 126: 114–122. Paper
Dellavance, A., Gallindo, C., Soares, M.G., Silva, N.P., Mortara, R.A. & Andrade, L.E.C. 2009. Redefining the Scl-70 indirect immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a specific immunofluorescence pattern. Rheumatology, 48: 632–637. Paper
Campos, F.M.F., Liarte, D.B., Mortara, R.A., Romanha, A.J., Murta, S.M.F. 2009. Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi. Acta Tropica, 111: 56-63. Paper
Gutiérrez, B., Osorio, L., Motta, C.C.M., Huima- Byron, T., Erdjument-Bromage, E., Muñoz, C., Sagua, H., Mortara, R.A., Echeverria, A., Araya, J.E. & Gonzalez, J. 2009. Molecular characterization and intracellular distribution of the alpha 5 subunit of Trypanosoma cruzi 20S proteasome. Parasitology International, 58: 367-374. Paper& Supplement
Bahia, D., Oliveira, L.M., Lima, F.M., Oliveira, P., Yoshida, N., Silveira, J.F., Mortara, R.A. & Ruiz, J.C. 2009. The TryPIKinome of five pathogenic trypanosomatids: Trypanosoma brucei,T. cruzi, Leishmania major, L. braziliensis and L. infantum. New tools for designing specific inhibitors. Biochemical and Biophysical Research Communications, 390: 963-970. Paper
Mortara, R.A., Andreoli, W.K., Fernandes, M.C., Silva, C.V., Fernandes, A.B., L’Abbate, C., & Silva, S. 2008. Host cell actin remodelling in response to Trypanosoma cruzi: trypomastigote versus amastigote entry. In: Molecular Mechanism of Parasite Invasion. Chapter 8. Ed. Barbara Burleigh & Dominique Soldati-Favre. Landes Bioscience and Springer Science+Business Media, Austin, Texas. pp. 101-108. Subcellular Biochemistry, 47: 101-109. Chapter
Quinto, B.M.R., Andrade, M.C.C., Ronchi, F.A., Santos, E.L., Correa, S.A.C., Shimuta, S.I., Pesquero, J.B., Mortara, R.A. & Casarini, D.E. 2008. Expression of Angiotensin I-converting enzymes and Bradykinin B2 receptors in mouse inner medullary collecting duct cells. International Immunopharmacology, 8: 254–260. Paper
Coulson-Thomas, Y.M., Coulson-Thomas, V.J., Filippo, T.R., Mortara, R.A., Silveira, R.B. Nader, H.B. & Porcionatto, M.A. 2008. Adult bone marrow-derived mononuclear cells expressing chondroitinase AC transplanted into CNS injury sites promote local brain chondroitin sulphate degradation. Journal of Neuroscience Methods, 171: 18-29. Paper
Mendes, P.F.P., Xander, P., Brito, R.R.N., Mortara, R.A., Jasiulionis, M.G., & Lopes, J.D. 2008. A cell surface 230 kDa protein from murine melanoma involved with tumor malignancy. Cancer Letters, 262: 276–285. Paper
Hernandes, R.T., Silva, R.M. Carneiro, S.M., Salvador, F.A., Fernandes, M.C., Padovan, A.C., Yamamoto, D., Mortara, R.A., Elias, W.P., Briones, M.R.S. & Gomes, T.A.T. 2008. The localized adherence pattern of an atypical enteropathogenic Escherichia coli is mediated by intimin omicron and unexpectedly promotes HeLa cell invasion. Cellular Microbiology,10: 415-425. Paper
Fukuzawa, A.H., Vellutini, B.C., Lorenzini, D.M., Silva Jr., P.I., Mortara, R.A., Silva, J.M.C. & Daffre, S. 2008. The role of hemocytes on the immunity of spider Acanthoscurria gomesiana. Developmental and Comparative Immunology, 32: 716-725. Paper
Rodrigues, E.G., Dobroff, A.S., Cavarsa, C.F., Paschoalin, T., Nimrichter, L., Mortara, R.A., Santos, E.L., Fazio, M.A., Miranda, A., Daffre, S., Travassos, L.R. 2008. Effective topical treatment of subcutaneous murine B16F10-Nex2 melanoma by the antimicrobial peptide gomesin. Neoplasia, 10: 61-68. Paper
Dallagiovanna, B., Correa, A., Probst, C.M., Holetz, F., Smircich, P., Aguiar, A.M., Mansur, F., Silva, C.V., Mortara, R.A., Garat, B., Buck, G.A., Goldenberg, S. & Krieger, M.A. 2008. Functional genomic characterization of mRNAs associated with TcPUF6, a Pumilio-like protein from Trypanosoma cruzi. The Journal of Biological Chemistry, 288: 8266-8273. Paper & Suppl. 1
Silva, E.R., Fischer, H., Silva, M.F.L., Mortara, R.A., Mayer, M.G., Framesqui, K., Silber, A.M. & Floeter-Winter. L.M. 2008. Biochemical and biophysical properties of Leishmania (Leishmania) amazonensis arginase used for purification of a highly active recombinant enzyme and for validation of a computational structural model. Molecular and Biochemical Parasitology, 159: 104-111. Paper
Santos, R.I.M., Rodrigues, A.H., Silva, M.L., Mortara, R.A., Rossi, M.A., Jamur, M.C., Oliver, C. & Arruda, E. 2008. Oropuche virus entry into HeLa cells involves clathrin and requires endosomal acidification. Virus Research, 138: 139-143. Paper
Fernandes, M.C., Cortez, M., Yoneyama, K.A.G., Straus, A.H., Yoshida, N. & Mortara, R.A. 2007. Novel strategy in Trypanosoma cruzi cell invasion: implication of cholesterol and host cell microdomains. International Journal for Parasitology, 37: 1431-1441. Paper
Fernandes, M.C., L’Abbate, C., Andreoli, W.K. & Mortara, R.A. 2007. Trypanosoma cruzi cell invasion and traffic: influence of Coxiella burnetii and pH in a comparative study between distinct infective forms. Microbial Pathogenesis, 43: 22-36. Paper
Elias, M.C., Cunha, J.P.C., Faria, F.P., Mortara, R.A., Freymuller, E. & Schenkman, S. 2007. Morphological events during Trypanosoma cruzi cell cycle. Protist, 158: 147-157. Paper
Feitosa, L.S., Soares, C.M.A., Santos, M.R.M., Bailão, A.M., Xander, P., Mortara, R.A. & Lopes, J.D. 2007. Cloning, characterization and heterologous expression of a calnexin homologue from the pathogenic fungus Paracoccidioides brasiliensis. Yeast, 24: 79-87. Paper
Levano-Garcia, J., Mortara, R.A., Verjovski-Almeida, S. & DeMarco, R. 2007. Characterization of Schistosoma mansoni ATPDase2 gene, a novel apyrase family member. Biochemical and Biophysical Research Communications, 352: 384–389. Paper
Bahia, D., Mortara, R.A., Kusel, J.R., Andrade, L.F., Ludolf, F., Kuser, P.R., Avelar, L., Trolet, J., Dissous, C., Pierce, R. & Oliveira, G. 2007. Schistosoma mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Experimental Parasitology, 116: 225-232. Paper
Coimbra, V.C., Yamamoto, D., Khusal, K.G., Atayde, V.D., Fernandes, M.C.D.C., Mortara, R.A., Yoshida, N., Alves, M.J.M. & Rabinovitch, M. 2007. Enucleated L929 cells support invasion, differentiation and multiplication of Trypanosoma cruzi parasites. Infection and Immunity, 75: 3700-3706. Paper
Taniwaki, N.N., Silva, C.V., Silva, S. & Mortara, R.A. 2007. Distribution of Trypanosoma cruzi stage-specific epitopes in cardiac muscle of Calomys callosus, BALB/c mice, and cultured cells infected with different infective forms. Acta Tropica, 103: 14-25. Paper
Miguel, D.C., Yokoyama-Yasunaka, J.K.U., Andreoli, W.K., Mortara, R.A. & Uliana, S.R.B. 2007. Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (L.) amazonensis amastigotes. Journal of Antimicrobial Chemotherapy, 60: 526-534. Paper
Salay, G. Dorta, M.L., Santos, N.M., Mortara, R.A., Brodskyn, C., Oliveira, C.I., Barbiéri, C.L. & Rodrigues, M.M. 2007. Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clinical and Vaccine Immunology, 14: 1173-1181. Paper
Okuda, K., Almeida, F., Mortara, R.A., Krieger, H., Marinotti, O. & Bijovsky, A.T. 2007. Cell death and regeneration in the midgut of the mosquito Culex quinquefasciatus. Journal of Insect Physiology, 53: 1307-1315. Paper
Xander, P., Vigna, A.F., Feitosa, L.S., Bailão, A.M., Soares, C.M.A., Mortara, R.A., Mariano, M. & Lopes, J.D. 2007. A surface 75 kDa protein with acid phosphatase activity recognized by monoclonal antibodies that inhibit Paracoccidioides brasiliensis growth. Microbes and Infection, 9: 1484 -1492. Paper
Ferreira, C.A.G., Rodrigues, E.G., Mortara, R.A., Cabral, H., Serrano, F.A., Ribeiro-dos-Santos, R. & Travassos, L.R. Anti-tumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cystein proteinase from Bromelia fastuosa. Neoplasia, 9: 723-733. Paper
Andreoli, W.K., Taniwaki, N.N., & Mortara, R.A. 2006. Survival of Trypanosoma cruzi metacyclic trypomastigotes within Coxiella burnetii vacuoles: differentiation and replication within an acidic milieu. Microbes and Infection, 8: 172-182. Paper
Andrade, M.C.C., Di Marco, G.S., Teixeira, V.P.C., Mortara, R.A., Sabatini, R.A., Pesquero, J.B., Boim, M.A., Carmona, A.K., Schor, N. & Casarini, D.E. 2006. Expression and localization of N-domain angiotensin I-converting enzymes (ACE) in mesangial cells in culture from spontaneously hypertensive rats (SHR). American Journal of Physiology: Renal Physiology, 290: 364-375. Paper & Corrigenda
Taniwaki, N.N., Machado, F.S., Massensini, A.R. & Mortara, R.A. 2006. Trypanosoma cruzi disrupts myofibrillar organization and intracellular calcium levels in mouse cardiomyocytes. Cell and Tissue Research, 324: 489-496. Paper
Rocha, G.M., Brandão, B.A., Attias, M., Mortara, R.A., de Souza, W. & Carvalho, T.M.U. 2006. The flagellar attachment zone of Trypanosoma cruzi epimastigote forms. Journal of Structural Biology, 154: 89-99. Paper
Laurino, C.F.C., Fritzler, M.J., Mortara, R.A., Silva, N.P., Almeida, I.C. & Andrade, L.E.C. 2006. Human autoantibodies to diacylphosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains. Clinical and Experimental Immunology, 143: 572–584. Paper
Cardoso, F.C., Pacífico, R.N.A., Mortara, R.A. & Oliveira, S.C. 2006. Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies. Clinical and Experimental Immunology, 144: 382-39. Paper
Silva, C.V., Luquetti, A.O., Rassi, A. & Mortara, R.A. 2006. Involvement of Ssp-4-related carbohydrate epitopes in mammalian cell invasion by Trypanosoma cruzi amastigotes. Microbes and Infection, 8: 2120-2129. Paper
Fernandes, A.B., Neira, I.T., Ferreira, A.T. & Mortara, R.A. 2006. Cell invasion by Trypanosoma cruzi amastigotes of distinct infectivities: studies on signaling pathways. Parasitology Research, 100: 59-68. Paper
Campanelli, A.P., Roselino, A.M., Cavassani, K.A., Pereira, M.S.F., Mortara, R.A., Brodskyn, C.I., Gonçalves, H.S., Belkaid, Y., Barral-Netto, M., Barral, A., Silva, J.S. 2006. The CD4+ CD25+ T cells of skin lesions from cutaneous leishmaniasis patients exhibit phenotypic and functional properties of regulatory T cells. The Journal of Infectious Diseases, 193:1313-1322. Paper
Bahia, D., Avelar, L., Freire, L., Mortara, R.A., Khayath, N., Yan, Y., Noël, C., Capron, M., Dissous, C., Pierce, R.J., & Oliveira, G. 2006. SmPKC1, a new protein kinase C identified in the platyhelminth parasite Schistosoma mansoni. Biochemical and Biophysical Research Communications, 345: 1138-1148. Paper
Macêdo, C.D.S., DaRocha, W.D., Mortara, R.A., Prado, M.A. & Teixeira, S.M.R. 2006. Characterization of a Trypanosoma cruzi antigen with homology to intracellular mammalian lectins. International Journal for Parasitology, 36:1473-1484. Paper
Bahia, D., Freire, L., Ludolf, F., Mortara, R.A. & Oliveira, G. 2006. Protein tyrosine kinases in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz (Rio de Janeiro), 101 (Suppl. I) 137-143. Paper
Coelho, A.C., Yamashiro, E.H., Bastos, S.F., Mortara, R.A. & Cotrim, P.C. 2006. Intracellular location of the ABC transporter PRP1 related to pentamidine resistance in Leishmania major. Molecular and Biochemical Parasitology, 150: 378–383. Paper
Bahia, D., Avelar, L.G.A., Vigorosi, F., Cioli, D., Oliveira, G.C. & Mortara, R.A. 2006. The distribution of motor proteins in the muscles and flame cells of the Schistosoma mansoni miracidium and primary sporocyst. Parasitology, 133: 321-329. Paper
Ganiko, L., Martins, A.R., Freymüller, E., Mortara, R.A. & Roque-Barreira, M.C. 2005. Lectin KM+-induced neutrophil haptotaxis involves binding to laminin. Biochimica etBiophysica Acta (General Subjects), 1721: 152-163. Paper
Mortara, R.A., Andreoli, W.K., Taniwaki, N.M., Fernandes, A.B., Silva, C.V., Fernandes, M.C, L’Abbatte, C. & Silva, S. 2005. Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms. Annals of the Brazilian Academy of Sciences, 77: 1-18. Paper
Bogsan, C.S.B., Brito, R.R.N, Palos, M.C., Mortara, R.A., Almeida, S.R., Lopes, J.D. & Mariano, M. 2005. B-1 cells are pivotal for in vivo inflammatory giant cell formation. International Journal of Experimental Pathology, 86: 257-265. Paper
Taniwaki, N.N., Andreoli, W.K. & Mortara, R.A. 2005. Disruption of myofibrillar proteins in cardiac muscle of Calomys callosus chronically infected with Trypanosoma cruzi and treated with immunosuppressive agent. Parasitology Research, 97: 323-33. Paper
Alberio, S.O., Dias, S.S., Faria, F.P., Mortara, R.A., Barbiéri, C.L. & Haapalainen, E.F. 2004. Ultrastructural and cytochemical identification of megasome in Leishmania (Leishmania) chagasi. Parasitology Research, 92: 246-254. Paper
Abreu-Silva, A.L., Calabrese, K.S., Mortara, R.A., Tedesco, R.C., Cardoso, F.O.; Carvalho, L.O.P. & Gonçalves Da Costa, S.C. 2004. Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection. Parasitology, 128: 385–390. Paper
Tempone, A.G., Vieira, D.P., Rath, S., Vilarinho, A.L., Mortara, R.A. & Andrade Jr., H.F. 2004. Targeting drugs to Leishmania (L.) chagasi amastigotes in macrophages: interaction of liposomes containing phosphatidylserine with scavenger receptors. Journal of Antimicrobial Chemotherapy, 54: 60-68. Paper
Fernandes, A.B. & Mortara, R.A. 2004. Invasion of MDCK epithelial cells with altered expression of Rho GTPases by Trypanosoma cruzi amastigotes and metacyclic trypomastigotes of strains from the two major phylogenetic lineages. Microbes and Infection, 6: 460-467. Paper
Silva, N.P., Christofolini, D.M., Mortara, R.A., & Andrade, L.E.C. 2004. Colocalization of coilin and nucleolar proteins in micronucleated PtK2 cells. Brazilian Journal of Medical and Biological Research, 37: 997-1003. Paper
Araujo, J.C., Mortara, R.A., Campos, J.R. & Vazoller, R.F. 2004. Development and analysis of anaerobic biofilms onto hydrophobic and hydrophilic surfaces. Environmental Technology, 25: 809-817. Paper
Maria-Engler, S.S., Krohl, K. Corrêa-Gianella, M.L., Silva, F.L., Aita, C.A.M., Oliveira, E.M.C., Corrêa, T.C.S., Silva I.C., Genizi, T., Miranda, M.P., Noronha, I.L., Mortara, R.A., Eliaschweitz, F.G., & Sogayar, M.C. 2004. Co-localization of nestin and insulin and expression of islet cell markers in long-term human pancreatic nestin-positive cell cultures. Journal of Endocrinology, 183: 455-467. Paper
Andreoli, W.K. & Mortara, R.A. 2003. Acidification modulates the traffic of Trypanosoma cruzi trypomastigotes in Vero cells harboring Coxiella burnetti vacuoles. International Journal for Parasitology, 33: 185-197. Paper
Verbisck, N.V., Santos, M.R.M., Engman, D., Chiurillo, M.A., Ramirez, J.L., Araya, J.E., Mortara, R.A. & Franco da Silveira, J. 2003. A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz (Rio de Janeiro), 98: 129-133. Paper
Abreu-Silva, A.L., Calabrese, K.S., Tedesco, R.C., Mortara, R.A. & Gonçalves da Costa, S.C. 2003. Central nervous system involvement in experimental Leishmania (L.) amazonensisinfection. American Journal of Tropical Medicine and Hygiene, 68: 661–665. Paper
Calabrese, K.S., Paradela, A.S.R.C., Zaverucha do Valle, T., Tedesco, R.C., Leonardo, R., Mortara, R.A. & Gonçalves da Costa, S.C. 2003. Confocal microscopy analysis of myocardial inflammatory infiltrates in mice treated with cyclophosphamide during acute Trypanosoma cruzi infection. Pathologie-Biologie (Paris), 51: 129-134. Paper
Feitosa, L.S., Cisalpino, P.S., Santos, M.R.M., Mortara, R.A., Bastos, T.F., Morais, F.V., Puccia, R., Franco da Silveira, J. & Camargo, Z.P. 2003. Chromosomal polymorphism, syntenic relationships and ploidy in the pathogenic fungus Paracoccidioides brasiliensis. Fungal Genetics and Biology, 39: 60-69. Paper
Araya, J., Silva, S., Mortara, R.A., Manque, P., Cordero, E., Neira, I., Sagua, H., Loyola, A., Bórquez, J ., Morales, G. & González, J. 2003. Diterpenoids fom Azorella compacta(Umbelliferae) active on Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz (Rio de Janeiro), 98: 413-418. Paper
Dias, N., Mortara, R.A. & Lima, N. 2003. Morphological and physiological changes in Tetrahymena pyriformis for the in vitro cytoxicity assessment of Triton X-100. Toxicology in Vitro, 17: 357-366. Paper
González, J., Cornejo, A., Santos, M.R.M., Cordero, E.M., Gutiérrez, B., Porcile, P., Mortara, R.A., Sagua, H., Silveira, J.F. & Araya, J.E. 2003. A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi. Biochemical Journal, 374: 647-656. Paper
De Marco, R., Kowaltowski, A.T., Mortara, R.A. & Verjovski-Almeida, S. 2003. Molecular characterization and immuno-localization of Schistosoma mansoni ATP-diphosphohydrolase. Biochemical and Biophysical Research Communications, 307: 831-838. Paper
Stecconi-Silva, R., Andreoli, W.K. & Mortara, R.A. 2003. Parameters affecting cellular invasion and escape from the parasitophorous vacuole by different infective forms of Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz (Rio de Janeiro), 98: 953-958. Paper
Abrahão, T.B., Freymüller, E., Mortara R.A., Lopes, J.D. & Mariano, M. 2003. Morphological characterization of mouse B-1 cells. Immunobiology, 208: 401-411. Paper
Zamboni, D.S., Freymuller, E., Mortara, R.A. & Rabinovitch, M. 2002. Mouse resident peritoneal macrophages partially control in vitro infection with Coxiella burnetii phase II. Microbes and Infection, 4: 591-598. Paper
Poli, P., Mello, M.A., Buschini, A., Mortara, R.A., Albuquerque, C.N., Silva, S., Rossi, C. & Zucchi, T.M.A.D. 2002. Cytotoxic and genotoxic effects of megazol, an anti-Chagas' disease drug, assessed by different short-term tests. Biochemical Pharmacology, 64: 1617-1627. Paper
Elias, M.C.Q.B., Faria, M., Mortara, R.A., Motta, M.C.M., De Souza, W., Thiry, M. & Schenkman, S. 2002. Chromosome localization changes in the Trypanosoma cruzi nucleus. Eukaryotic Cell, 1: 944-953. Paper
Zamboni, D.S., Mortara, R.A. & Rabinovitch, M. 2001. Infection of Vero cells with Coxiella burnetii phase II: Relative intracellular bacterial load estimated by confocal laser scanning microscopy. Journal of Microbiological Methods, 43: 223-232. Paper
Carmo, M.S., Santos, M.R.M., Cummings, L.M., Araya, J.E., Yamauchi, L.M., Yoshida, N., Mortara, R.A. & Franco da Silveira, J. 2001. Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine, and proline-rich protein of Trypanosoma cruzi. International Journal for Parasitology, 31: 259-264. Paper
Mortara, R.A., Minelli, L.M.S., Vandekerckhove, F., Nussenzweig, V. & Ramalho-Pinto, F.J. 2001. Phosphatidylinositol- specific phospholipase C (PI-PLC) cleavage of GPI-anchored surface molecules of Trypanosoma cruzi triggers in vitro morphological reorganization of trypomastigotes. Journal of Eukaryotic Microbiology, 48: 27-37. Paper
This work was awarded the 2001 William Trager Award for Outstanding Paper of the Year, Society of Protozoologists (EUA)
Marcelino de Souza, M., Franco, M., Almeida, D.R., Diniz, R.V., Mortara, R.A., Silva, S. & Patrício, F.R.S. 2001. Comparative histopathology of endomyocardial biopsies in chagasic and non-chagasic heart transplant recipients. The Journal of Heart and Lung Transplantation, 20: 534-543. Paper
Linares, E., Giorgio, S., Mortara, R.A., Santos, C.X.C., Yamada, A.T. & Augusto, O. 2001. Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation. Free Radical Biology & Medicine, 30: 1234-1242. Paper
Suzuki, E., Mortara, R.A.,Takahashi, H.K. & Straus, A.H. 2001. Reactivity of MEST-1 (antigalactofuranose) with Trypanosoma cruzi glycosylinositol phosphoceramides (GIPCs): immunolocalization of GIPCs in acidic vesicles of epimastigotes. Clinical and Diagnostic Laboratory Immunology, 8: 1031-1035. Paper
Mortara, R.A., Silva, S. & Taniwaki, N.N. 2000. Confocal fluorescence microscopy: a powerful tool in the study of Chagas' disease. Revista da Sociedade Brasileira de Medicina Tropical, 33: 79-82. Paper
Calabrese, K.S., Paradela, A.S.R.C., Zaverucha do Valle, T., Tedesco, R.C., Silva, S., Mortara, R.A. & Gonçalves da Costa, S.C. 2000. Study of acute chagasic mice under immunosuppressive therapy by cyclosporin A: modulation and confocal analysis of inflammatory reaction. Immunopharmacology, 47: 1-11. Paper
Baqui, M.M., Milder, R., Mortara, R.A. & Pudles J. 2000. In vivo and in vitro phosphorylation and subcellular localization of trypanosomatid cytoskeletal giant proteins. Cell Motility and the Cytoskeleton, 47: 25-37. Paper
1978 - 1999
Procópio, D.O., Barros, H.C. & Mortara, R.A. 1999. Actin-rich structures formed during the invasion of cultured cells by infective forms of Trypanosoma cruzi. European Journal of Cell Biology, 78: 911-924. Paper
Mortara, R.A., Procópio, D.O., Barros, H.C., Verbisck, N.V., Andreoli, W.K., Silva, R.B.S. & Silva, S. 1999. Features of host cell invasion by different infective forms of Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, 94 Suppl I: 135-137. Paper
Rabinovitch M., Freymuller E., de Paula R.A., Manque, P., Andreoli, W.K & Mortara, R.A. 1999. Cell co-infections with non-viral pathogens and the construction of doubly infected phagosomes. In: Phagocytosis: microbial invasion. Gordon S., editor. Series: Advances in Cell and Moleclar Biology of Membranes and Organelles, Volume 6, JAI Press Inc. Stamford, Connecticut., 349-371. Chapter
Mortara, R.A., Silva, S., Patrício, F.R; Higuchi, M.L., Lopes, E.R.; Gabbai, A.A., Carnevale, P., Rocha, A., Ferreira, M.S., Souza, M.M., Franco, M.S., Turcato Jr., G., Ferraz-Neto, B.H. 1999. Imaging Trypanosoma cruzi within tissues from chagasic patients using confocal microscopy with monoclonal antibodies. Parasitology Research, 85: 800-808. Paper
Ferro, E.A.V., Bevilacqua, E., Favoreto Jr., S., Silva, A.O., Mortara, R.A. & Mineo, J.R. 1999. Calomys callosus trophoblast cells (Rodentia: Cricetidae) as host cells to Toxoplasma gondii in early pregnancy. Parasitology Research, 85: 647-654. Paper
Ramirez, M.I., Boscardin, S.B., Ruiz, R.C., Han, S.W., Paranhos-Baccalà, G.S., Yoshida, N., Mortara, R. A. & Franco da Silveira, J. 1999. Heterologous expression of a Trypanosoma cruzi surface glycoprotein (GP82) indicates that requirements for glycosylphospohatidylinositol anchoring are different in mammalian cells and this trypanosome. Memórias do Instituto Oswaldo Cruz, 94: 527-530. Paper
Ramirez, M.I., Boscardin, S.B., Han, S.W., Paranhos-Baccalà, G.S., Yoshida, N., Kelly, J.M., Mortara, R.A. & Franco da Silveira, J. 1999. Heterologous expression of a Trypanosoma cruzi surface glycoprotein (GP82) in mammalian cells indicates the existence of different signal sequence requirements and processing. Journal of Eukaryotic Microbiology, 46: 557-565. Paper
Procópio, D.O., Da Silva, S., Cunningham, C.C. & Mortara, R.A. 1998. Trypanosoma cruzi: Effect of protein kinase inhibitors nd cytoskeletal protein organization and expression on host cell invasion by amastigotes and metacyclic trypomastigotes. Experimental Parasitology, 90: 1-13. Paper
Verbisck, N.V., Da Silva, S. & Mortara, R.A. 1998. Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies. Brazilian Journal of Medical and Biological Research, 31: 1583-1591. Paper
Balanco, J.M.F., Pral, E.M.F., Bijovsky, A.T., Mortara, R.A., Silva, S. & Alfieri, S.C. 1998. Axenic cultivation and partial characterization of Leishmania braziliensis amastigote-like stages. Parasitology, 116: 103-113. Paper
Cano, M.I., Cisalpino, P.S., Galindo, I., Ramirez, J.L., Mortara, R.A. & Franco da Silveira, J. 1998. Electrophoretic karyotypes genome sizing of the pathogenic fungus Paracoccidioides brasiliensis. Journal of Clinical Microbiology, 36: 742-747. Paper
Barros, H.C., Verbisck, N.V., Da Silva, S., Araguth, M.F. & Mortara, R.A. 1997. Distribution of epitopes of Trypanosoma cruzi amastigotes during the intracellular life cycle within mammalian cells. Journal of Eukaryotic Microbiology, 44: 275-285. Paper
Yoshida, N., Dorta, M.L., Ferreira, A.T., Oshiro, M.E.M., Mortara, R.A., Acosta-Serrano, A. & Favoreto Jr., S. 1997. Removal of sialic acid from mucin-like surface molecules or Trypanosoma cruzi metacyclic trypomastigotes enhances parasite-host cell interaction. Molecular and Biochemical Parasitology, 84: 57-67. Paper
Lesénéchal, M., Duret, L., Cano, M.I., Mortara, R.A., Jolivet, M., Camargo, M.E., Franco da Silveira, J. & Paranhos-Baccalà, G. 1997. Cloning and characterization of a gene encoding a novel immunodominant antigen of Trypanosoma cruzi. Molecular and Biochemical Parasitology, 87: 193-204. Paper
Barros, H.C., Da Silva, S., Verbisck, N.V., Araguth, M.F., Tedesco, R.C., Procópio, D.O. & Mortara, R.A. 1996. Release of membrane-bound trails by Trypanosoma cruzi amastigotes onto modified surfaces and mammalian cells. Journal of Eukaryotic Microbiology, 43: 275-285. Paper
Cotrim, P.C., Paranhos-Baccalà, G.S., Santos, M.R., Mortensen, C., Cano, M.I., Jovilet, M., Camargo, M.E., Mortara, R.A. & Franco da Silveira, J. 1995. Organization and expression of an imunodominant repetitive antigen associated to the cytoskeleton of Trypanosoma cruzi. Molecular and Biochemical Parasitology, 71: 89-98. Paper
Schenkman, S., Ferguson, M.A.J., Heise, N., Cardoso de Almeida, M.L., Mortara, R.A. & Yoshida, N. 1993. Mucin-like glycoproteins linked to the membrane by glycosyl-phosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalysed by trans-sialidase in metacyclic forms of Trypanosoma cruzi. Molecular and Biochemical Parasitology, 59: 293-304. Paper
Schenkman, S. & Mortara, R.A. 1992. HeLa cells extend and internalize pseudopodia during active invasion by Trypanosoma cruzi trypomastigotes. Journal of Cell Science, 101: 895-905. Paper
Mortara, R.A., Silva, S., Araguth, M.F., Blanco, S.A. & Yoshida, N. 1992. Polymorphism of the 35-50 kiloDalton surface glycoconjugates from Trypanosoma cruzi metacyclic trypomastigotes. Infection and Immunity, 60: 4673-4678. Paper
Mortara, R.A. 1991. Trypanosoma cruzi: amastigotes and trypomastigotes interact with different structures on the surface of HeLa cells. Experimental Parasitolology, 73: 1-14. Paper
Cotrim, P.C., Paranhos, G.S., Mortara, R.A., Wanderley, J., Rassi, A., Camargo, M.E. & Franco da Silveira, J. 1990. Expression in Escherichia coli of a dominant immunogen of Trypanosoma cruzi recognized by human chgasic sera. Journal of Clinical Microbiology, 28: 519-524. Paper
Paranhos, G.S., Cotrim, P.C., Mortara, R.A., Rassi, A., Corral, R., Freilij, H.L., Grinstein, S., Wanderley, J., Camargo, M.E. & Franco da Silveira, J. 1990. Trypanosoma cruzi: cloning and expression of an antigen recognized by acute and chronic human chagasic sera. Experimental Parasitology, 71: 284-293. Paper
Franco da Silveira, J., Paranhos, G.S., Cotrim, P.C., Mortara, R.A., Camargo, M.E., Rassi, A., Wanderley, J., Corral, R., Freilij, H.L., Grinstein, S. & Degrave, W. 1990. Antigens of Trypanosoma cruzi with clinical interest cloned and expressed in Escherichia coli. Memórias do Instituto Oswaldo Cruz (Rio de Janeiro), 85: 507-511.
Mortara, R.A. & Koch, G.L.E. 1989. An association between actin and nucleocapsid polypeptides in isolated murine retroviral particles. Journal of Submicroscopic Cytology and Pathology, 21: 295-306. Paper
Mortara, R.A. 1989. Studies on trypanosomatid actin. I. Immunochemical and biochemical identification. Journal of Protozoology, 36: 8-13. Paper
Silva, M.L.M., Mortara, R.A., Barros, H.C., De Souza, W. & Trabulsi, L.R. 1989. Aggregation of membrane-associated actin filaments following localized adherence of enteropathogenic Escherichia coli to HeLa cells. Journal of Cell Science, 93: 439-446. Paper
Yoshida, N., Mortara, R.A., Araguth, M.F., Gonzalez, J.C. & Russo, M. 1989. Metacyclic neutralizing effect of monoclonal antibody 10D8 directed to 35 and 50 kilodalton surface glycoconjugates of Trypanosoma cruzi. Infection and Immunity, 57: 1663-1667. Paper
Mortara, R.A., Araguth, M.F. & N. Yoshida. 1988. Reactivity of stage-specific monoclonal antibody 1G7 with metacyclic trypomastigotes of Trypanosoma cruzi strains: lytic property and 90,000 mol wt surface antigen polymorphism. Parasite Immunology, 10: 369-378. Paper
Cicilini, M.A., Ribeiro, M.J.F., Oliveira, E.B., Mortara, R.A. & Camargo, A.C.M. 1988. Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides. Peptides, 9: 945-956. Paper
Mortara, R.A. & Koch, G.L.E. 1986. Analysis of pseudopodial structure and assembly with viral projections. Journal of Cell Science, suppl. 5: 129-144. Paper
Koch, G.L.E., Macer, D., Smith, M.J., Webster, P. & Mortara, R.A. 1986. Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin. Journal of Cell Science, 86: 217-232. Paper
Koch, G.L.E., Smith, M.J. & Mortara, R.A. 1985. An abundant, ubiquitous glycoprotein (GP100) in nucleated mammalian cells. FEBS Letters, 179: 294-298. Paper
Cuccovia, I.M., Aleixo, R.M.V., Mortara, R.A., Berci Fo., P., Bonilha, J.B.S., Quina,F.H. & Chaimovich, H. 1979. Effect of dimethyl dialkylammonium vesicles on the thiolysis of p-nitrophenyl acetate. Tetrahedron Letters, 20: 3065-3068. Paper
Mortara, R.A., Quina, F.H. & Chaimovich, H. 1978. Formation and properties of closed vesicles from a simple phosphate diester. Preparation and some properties of vesicles of di- hexadecylphosphate. Biochemical and Biophysical Research Communications, 81: 1080-1086. Paper